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KMID : 1023120130110061067
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Korean Journal of Aesthetic Society
2013 Volume.11 No. 6 p.1067 ~ p.1072
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Anti-obese Activity of Water Extract Prepared from Green-shelled Mussel through Regulating Adipogenesis
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Shon Myung-Soo
Kim Si-Kyung
Lee Seung-Cheol
Kim Gyo-Nam
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Abstract
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Adipogenesis was defined as a differentiation process of preadipocytes into adipocytes. It is a key process in determining the number of mature adipocytes in the development of obesity. Thus, to regulation of adipogenesis is crucial target in obesity prevention. Mussel (Mytilus corscus ) has been reported to possess abundant dietary proteins and savory amino acids. However, antiadipogenic role and function in obesity prevention remains unknown. Here, we employed green-shelled mussel and its water extract (GME) was prepared. To elucidate the potential role of GME in 3T3-L1 adipogenesis, 3T3-L1 cells were treated with GME between day ?2 to day 6. We found that GME dose-dependently suppressed adipogenesis and inhibited formation of lipid droplets accompanied by reduced level of adipogenic transcriptional factors such as C/EBPα and FAS. Our study further revealed that inhibitory function of GME wa largely limited to the adipogenesis day 0 to day 6. Taken together, our evidences provide new insights into the molecular basis underlying the antiadipogenic function of GME.
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KEYWORD
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Obesity, Adipogenesis, Green-shelled mussel, 3T3-L1, Adipogenic genes
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